Image credit: C. Blanpain, V. Horsley, E. Fuchs, Epithelial stem cells: turning over new leaves, Cell, 128 (2007), p. 445.
Image adapted from: http://medical-dictionary.thefreedictionary.com/limbus
Image credit: T. Phesse, A. Clarke, Normal stem cells in cancer prone epithelial tissues, Br J Cancer, 100 (2009), p.221.
Image credit: C. Blanpain, E. Fuchs, Plasticity of epithelial stem cells in tissue regeneration, Science, 344 (2014), p.1242281.
Image credit: T. Phesse, A. Clarke, Normal stem cells in cancer prone epithelial tissues, Br J Cancer, 100 (2009), p.221.
Image credit: C. Blanpain, E. Fuchs, Plasticity of epithelial stem cells in tissue regeneration, Science, 344 (2014), p.1242281.
Image credit: C. Blanpain, E. Fuchs, Plasticity of epithelial stem cells in tissue regeneration, Science, 344 (2014), p.1242281.
WHERE can you find ESCs?
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ESCs reside in the linings of the body's surfaces:
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Internal - lining of the intestine, vessels, & other cavities.
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External - skin epidermis and its appendages (hair follicles, sebaceous glands, sweat glands).
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Hair Follicle Bulge Region
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ESCs in the bulge of the hair follicle are in different states to adjust to the regenerative demand of wounded tissue and maintain tissue homeostasis.
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​Stem cells are in two states - active and quiescent (i.e. idle)
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Primed stem cells (blue in above image) respond quickly to tissue needs.
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Precusor cells to the primed cells are short lived (orange).
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Intestine
Mammary Gland
Lungs
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Intestinal crypt ESCs (green) are found near the base of the crypt between paneth cells
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Lung ESCs are at the junction between the bronchial region and the alveolar sac
Prostate Gland
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Prostatic ESCs are located in basal cells that surround the columnar secretory cells of the distal prostatic duct
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Expansion of the mammary gland during puberty and pregnancy is possible because of mammary stem cells called myoepithelial cells (red)
Cornea
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Corneal stem cells reside in the limbus region of the eye
